Anti Ulcerogenic & Ulcer Healing Studies of Aqueous Extract of Pueraria Tuberosa Leaves on Rats

نویسندگان

  • SUMALATHA GINDI
  • BAHLUL Z AWEN
  • CHANDU BABURAO
  • MUKKANTI KHAGGA
چکیده

In this study, the anti ulcerogenic effect of water extract obtained from the leaves of Pueraria Tuberosa[PT] was investigated using cold restraint stress(CRU), pyloric ligation(PL) & Ethanol induced (EtOH) induced gastric ulcer models in rats. The treatment with PT at higher dose significantly inhibited gastric lesions induced by CRU (76.6%), PL (80.1%) & EtOH (70.6%) respectively with equal potency of Omeperazole. In addition the effects of PT on HKATPase activity was determined. PT significantly inhibited HKATpase activity in EtOH induced ulcer model. PT accelerated the healing of EtOH induced ulcers by inhibiting HKATPase activity.

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تاریخ انتشار 2010